abstract：:Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neop...

journal_title：Clinical and experimental medicine

authors： Tahara T,Shibata T,Okubo M,Kawamura T,Sumi K,Ishizuka T,Nakamura M,Nagasaka M,Nakagawa Y,Ohmiya N,Arisawa T,Hirata I

更新日期：2015-08-01 00:00:00

abstract：:Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in immune regulation in the context of infection, autoimmunity, and angiogenesis. In this study, we aimed to investigate the possible pathophysiological role of IL-27 and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS)....

journal_title：Clinical and experimental medicine

authors： Lin TT,Lu J,Qi CY,Yuan L,Li XL,Xia LP,Shen H

更新日期：2015-05-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...

journal_title：Clinical and experimental medicine

authors： Filip AA,Ciseł B,Wąsik-Szczepanek E

更新日期：2015-02-01 00:00:00

abstract：:To establish a serological classification tree model for rheumatoid arthritis (RA), protein/peptide profiles of serum were detected by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) from Cohort 1, including 65 patients with RA and ...

journal_title：Clinical and experimental medicine

authors： Yan Z,Chaojun H,Chuiwen D,Xiaomei L,Xin Z,Yongzhe L,Fengchun Z

更新日期：2015-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have captured the attention of researchers today due to their multipotent differentiation capacity. Also, they have been successfully applied clinically, in the treatment of various diseases of the heart and musculoskeletal systems, with encouraging results. Their supportive role in haema...

journal_title：Clinical and experimental medicine

authors： Wong RS,Cheong SK

更新日期：2014-08-01 00:00:00

abstract：:The objective of this study was to compare between the effects of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis. Sixty male albino mice were divided equally into 2 models. They are MSC model, group 1: saline control group, group 2: collagen-induced arthritis (CIA), group 3: ind...

journal_title：Clinical and experimental medicine

authors： El-Denshary ES,Rashed LA,Elhussiny M

更新日期：2014-08-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...

journal_title：Clinical and experimental medicine

authors： Wu BQ,Luo JM,Wang YH,Shi YF,Liu H,Ba JH,Zhang TT

更新日期：2014-05-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...

journal_title：Clinical and experimental medicine

authors： Yue Y,Zhong W,Pei G,Xiao B,Zhang G,Jiang F,Zhang J,Chen C,Yang P,Dang H,Chang H

更新日期：2013-11-01 00:00:00

abstract：:Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subject...

journal_title：Clinical and experimental medicine

authors： Hayashi R,Tahara T,Shiroeda H,Saito T,Nakamura M,Tsutsumi M,Shibata T,Arisawa T

更新日期：2013-11-01 00:00:00

abstract：:Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...

journal_title：Clinical and experimental medicine

authors： Wang K,Gong J,Pei L,Shan S,Tan W

更新日期：2013-08-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

journal_title：Clinical and experimental medicine

authors： Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

更新日期：2012-12-01 00:00:00

abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...

journal_title：Clinical and experimental medicine

authors： Zhang X,Yuan Z,Shen B,Zhu M,Liu C,Xu W

更新日期：2012-09-01 00:00:00

abstract：:Diabetes is one of the most common and challenging health problems. Studies in several nations show that polymorphisms within the transcription factor 7-like 2 genes could be associated with type 2 diabetes (T2D). Therefore, a case-control study was conducted to find the association between SNP rs7903146 and T2D in ou...

journal_title：Clinical and experimental medicine

authors： Palizban A,Nikpour M,Salehi R,Maracy MR

更新日期：2012-06-01 00:00:00

abstract：:The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibod...

journal_title：Clinical and experimental medicine

authors： Mansueto P,Pepe I,Seidita A,Scozzari F,Vitale G,Arcoleo F,Elvira I,Cillari E,Rini GB,Napoli N,Di Rosa S,Mansueto S,Di Fede G

更新日期：2012-06-01 00:00:00

abstract：:To investigate the expression of cyclin G1, cyclin G2 in nasopharyngeal carcinoma (NPC) cell lines and its significance. The protein expression of cyclin G1, cyclin G2 in NPC cell lines of different differentiation degree (HNE2, CNE1) was detected by indirect immunofluorescence. The mRNA expression of cyclin G1, cycli...

journal_title：Clinical and experimental medicine

authors： Ye XX,Liu CB,Chen JY,Tao BH,Zhi-Yi C

更新日期：2012-03-01 00:00:00

abstract：:Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in periphe...

journal_title：Clinical and experimental medicine

authors： Qin WZ,Chen LL,Pan HF,Leng RX,Zhai ZM,Wang C,Li RJ,Wang S,Wang HP,Ye DQ

更新日期：2011-12-01 00:00:00

abstract：:The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon 16 in the RET oncogene (ATG → ACG). The aim of this work was to develop a single oligoarray by using tandem hybridization to detect the T918C/RET mutation for MEN 2B patie...

journal_title：Clinical and experimental medicine

authors： Pacheco-Rivera RA,Hernández-Zamora E,González-Yebra B,Beattie K,Maldonado-Rodríguez R,Santiago-Hernández JC,Medrano-Ortiz de Zárate ME,Salcedo M

更新日期：2011-12-01 00:00:00

abstract：:Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...

journal_title：Clinical and experimental medicine

authors： Xie X,Chen JW,Li F,Tian J,Gao JS,Zhang D

更新日期：2011-09-01 00:00:00

abstract：:Recently, it was discovered that high mobility group box chromosomal protein 1 (HMGB1) acts as a potent pro-inflammatory cytokine that is released into the extracellular milieu. Signal transducer and activator of transcription (STAT) proteins play an important role in cytokine signaling. Some investigators have report...

journal_title：Clinical and experimental medicine

authors： Guo HF,Liu SX,Zhang YJ,Liu QJ,Hao J,Gao LX

更新日期：2011-06-01 00:00:00

abstract：:It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of e...

journal_title：Clinical and experimental medicine

authors： Radziejewska I,Borzym-Kluczyk M,Namiot Z,Stefańska E

更新日期：2011-06-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...

journal_title：Clinical and experimental medicine

authors： Wang D,Zhang H,Liang J,Gu Z,Ma X,Huang J,Lin J,Hou Y,Lu L,Sun L

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...

journal_title：Clinical and experimental medicine

authors： Nowak M,Wielkoszyński T,Marek B,Kos-Kudła B,Swietochowska E,Siemińska L,Karpe J,Kajdaniuk D,Głogowska-Szelag J,Nowak K

更新日期：2010-09-01 00:00:00

abstract：:STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...

journal_title：Clinical and experimental medicine

authors： Kim EG,Shin HJ,Lee CG,Park HY,Kim YK,Park HW,Cho SH,Min KU,Cho ML,Park SH,Lee CW

更新日期：2010-09-01 00:00:00

abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

journal_title：Clinical and experimental medicine

authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

更新日期：2010-09-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...

journal_title：Clinical and experimental medicine

authors： Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-06-01 00:00:00

abstract：:Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...

journal_title：Clinical and experimental medicine

authors： Charalampopoulos A,Charalabopoulos A,Batistatou A,Golias C,Anogeianaki A,Peschos D,Iliadis I,Macheras A,Charalabopoulos K

更新日期：2010-03-01 00:00:00

abstract：:Severe combined immunodeficiencies (SCID) comprise a spectrum of genetic defects that involve both humoral and cellular immunities. Defects in recombinating activating gene 1 (RAG1), RAG2, Artemis, or LIG4 can disrupt V(D)J recombination. Defective V(D)J recombination of the T and B cell receptors is responsible for T...

journal_title：Clinical and experimental medicine

authors： Karaca NE,Aksu G,Genel F,Gulez N,Can S,Aydinok Y,Aksoylar S,Karaca E,Altuglu I,Kutukculer N

更新日期：2009-12-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to infections, autoimmunity and malignancies. This study was performed to analyze the Mannose-binding lectin (MBL) polymorphisms in Iranian patients with CVID. Thirty-five ...

journal_title：Clinical and experimental medicine

authors： Aghamohammadi A,Foroughi F,Rezaei N,Dianat S,Solgi G,Amirzargar AA

更新日期：2009-12-01 00:00:00

abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...

journal_title：Clinical and experimental medicine

authors： Tong H,Lu C,Zhang J,Liu Z,Ma Y

更新日期：2009-06-01 00:00:00

abstract：:We have recently found that pigment epithelium-derived factor (PEDF), a glycoprotein with potent neuronal differentiating activity, not only inhibits endothelial cell damage, smooth muscle cell proliferation and platelet aggregation in vitro, but also suppresses occlusive thrombus formation in rats. These observations...

journal_title：Clinical and experimental medicine

authors： Yamagishi S,Matsui T,Nakamura K,Takenaka K

更新日期：2009-03-01 00:00:00

abstract：:Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...

journal_title：Clinical and experimental medicine

authors： Tsaroucha AK,Chatzaki E,Lambropoulou M,Despoudi K,Laftsidis P,Charsou C,Polychronidis A,Papadopoulos N,Simopoulos CE

更新日期：2008-09-01 00:00:00

abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...

journal_title：Clinical and experimental medicine

authors： Nanda N,Bobby Z,Hamide A

更新日期：2008-06-01 00:00:00

abstract：:High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...

journal_title：Clinical and experimental medicine

authors： Meng X,Li ZM,Zhou YJ,Cao YL,Zhang J

更新日期：2008-03-01 00:00:00

abstract：:Triglyceride-rich lipoproteins contain both apolipoproteins E (ApoE) and C-III (ApoC-III), which show opposite functional properties. The relationships between the ApoE (epsilon2/epsilon3/epsilon4) gene polymorphism and ApoC-III/ApoE ratio has never been investigated. A large population (n=552) of cardiovascular patie...

journal_title：Clinical and experimental medicine

authors： Olivieri O,Martinelli N,Bassi A,Trabetti E,Girelli D,Pizzolo F,Friso S,Pignatti PF,Corrocher R

更新日期：2007-12-01 00:00:00

abstract：:The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall survival, and it is now considered conventional therapy in younger patien...

journal_title：Clinical and experimental medicine

authors： Merchionne F,Perosa F,Dammacco F

更新日期：2007-09-01 00:00:00

abstract：:The present study was initiated to examine whether the concentration of CO in the breath is elevated in patients with inflammatory bowel disease (IBD). Twenty-three clinically stable patients with IBD in the outpatient clinic (11 with Crohn's disease, 12 with ulcerative colitis), who are non-smokers and non-passive sm...

journal_title：Clinical and experimental medicine

authors： Nitta H,Kinoyama M,Teramoto F,Watanabe A,Koga H,Haruma K,Akagi R,Ueda H

更新日期：2007-06-01 00:00:00

abstract：:The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...

journal_title：Clinical and experimental medicine

authors： Grujicić D,Milosević Djordjević O,Arsenijević S,Marinković D

更新日期：2007-03-01 00:00:00

abstract：:The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...

journal_title：Clinical and experimental medicine

authors： Kopjar N,Milas I,Garaj-Vrhovac V,Gamulin M

更新日期：2006-12-01 00:00:00

abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

journal_title：Clinical and experimental medicine

authors： Kamocka M,Kaplinska K,Mielicki WP

更新日期：2006-10-01 00:00:00

abstract：:This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to ...

journal_title：Clinical and experimental medicine

authors： Reichlin M

更新日期：2006-06-01 00:00:00